Plasticity in Hippocampal Peptidergic Systems Induced by Repeated Electroconvulsive Shock
نویسندگان
چکیده
منابع مشابه
Repeated Electroconvulsive Shock Produces Long-lasting Increases
Electroconvulsive shock (ECS) is a highly effective therapy for the treatment of major depression, but its mechanisms of action are not known. We report that repeated ECS in rats produces enduring changes in two clinically relevant stress-responsive brain systems: (a) the hypothalamic-pituitary-adrenal axis regulated by corticotropin-releasing hormone (CRH) in the paraventricular nucleus; and (...
متن کاملPropofol prevents electroconvulsive-shock-induced memory impairment through regulation of hippocampal synaptic plasticity in a rat model of depression
BACKGROUND Although a rapid and efficient psychiatric treatment, electroconvulsive therapy (ECT) induces memory impairment. Modified ECT requires anesthesia for safety purposes. Although traditionally found to exert amnesic effects in general anesthesia, which is an inherent part of modified ECT, some anesthetics have been found to protect against ECT-induced cognitive impairment. However, the ...
متن کاملEnhancement of serotonin(1A) receptor function following repeated electroconvulsive shock in young rat hippocampal neurons in vitro.
Effects of repeated electroconvulsive shock (ECS) treatment on 5-hydroxytryptamine (5-HT) response were investigated to elucidate the ECS-induced changes, which may be related to antidepressant effects, using electrophysiological methods with hippocampal slices in vitro. ECS was applied to Wistar rats once daily for 14 d from 3 wk of age (ECS group). Control animals did not receive ECS (control...
متن کاملShort- and long-term alterations of gene expression in limbic structures by repeated electroconvulsive-induced seizures.
Rats were submitted to a series of 10 daily electroconvulsive shocks (ECS). A first group of animals was killed 1 day after the last seizure and a second group 30 days later. Tyrosine hydroxylase (TH) activity was measured using an in vitro assay in the nucleus caudatus, anterior cortex, amygdala, substantia nigra, ventral tegmental area, and locus ceruleus. The mRNA corresponding to this enzym...
متن کاملSustained Expression of Neuritin mRNA After Repeated Electroconvulsive Stimulations in the Rat Hippocampal Formation
In the present study, we compared the expression patterns of neuritin mRNA in the dentate gyrus of hippocampal formation following single (1×ECS) or repeated elctroconvulsive seizures (8×ECS) treatments to the rat. The expression of neuritin mRNA was transiently increased, and returned to basal level within 12 hours after 1×ECS. Whereas initial induction of neuritin mRNA was similarly seen, the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2002
ISSN: 0893-133X
DOI: 10.1016/s0893-133x(02)00284-1